Photoaffinity labeling in target- and binding-site identification
نویسندگان
چکیده
منابع مشابه
Photoaffinity labeling in target- and binding-site identification.
Photoaffinity labeling (PAL) using a chemical probe to covalently bind its target in response to activation by light has become a frequently used tool in drug discovery for identifying new drug targets and molecular interactions, and for probing the location and structure of binding sites. Methods to identify the specific target proteins of hit molecules from phenotypic screens are highly valua...
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The known binding of a derivative of the COOH-terminal tetrapeptide of gastrin with high biological activity to bovine serum albumin suggests a convenient model system for testing the affinity labeling of hormone binding sites. Photolysis of 4-azidobenzoylpentagastrin, Z-nitro-5-azidobenzoylpentagastrin, 4-acetylbenzoylpentagastrin, and 4-benzoylbenzoylpentagastrin in the presence of bovine ser...
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Yi Xiong obtained his PhD degree in bioinformatics from Wuhan University, China, in 2011. He worked as a research assistant at the Department of Bioinformatics and Biostatistics in Shanghai Jiao Tong University, China, from 2009 to 2011. He is currently working as a postdoctoral research associate at the Department of Biological Sciences, Purdue University (IN, USA). He has published several sc...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2015
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.14.152